Base de dados : HANSEN
Pesquisa : ANTIGENO DE MITSUDA/EF ADV [Descritor de assunto]
Referências encontradas : 47 [refinar]
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  1 / 47 HANSEN  
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Texto Completo-pt
Id:26199
Autor:Faria, J. Lopes de.
Título:Estudo da reação à lepromina (Mitsuda) em cães: histopatologia, significação / Lerpomin reaction in dogs: histopathology, signification
Fonte:Rev. bras. Leprol;15(3):195-201, set. 1947. .
Resumo:In this paper, the author first revised what is known about lepromin (Mitsuda) reaction in man. From his review he believes worth-mentioning: the delay in the reaction (nodule); in Mitsuda's antigen bacilli ere indispensable for the development of the nodular phase; the production of late reaction with the waxez of Hansen's bacilli and alcohol-soluble and cloroform-soluble leproma fractions; normal persons without any previous contact with lepers (from non-endemic leprosy regions), presente the nodular reaction; its negativity in children. Next he points out the unsuccessful attempts to trasmit human leprosy to animals. Then he studies the hsitopatology of the hyperergic inflammation, emphasizing the fibrinoid degeneration of the connective tissue, because of Bngeler and Fernandez's paper. He analyses the causative pathogenesis of the tubercle and tuberculoid structures, the mechanism of the necrosis found in inflammatory granulomas and also why the tubercle is invaded by such a great number of neutrophil leukocytes. In the other part of the paper, the author reports his experiments, He made careful macroscopic and microscopic studies of lepromim reaction in ten adult dogs from non leprous communities. He used, as control substances, a normal skin extract (prepared by the same technic of lepromin) and saline. He examined the reactions which take palce within: 5 minutes; 1, 24 and 48 hours; 4, 8, 15, 21, 30, 60 and 90 days. The initial dermic paule (injection paule) to lepromin increased a little (2,2 mm) within the first five minutes and kept growing (1,5 mm more) until the firts hour in half of the animals; then it decreased more and more and disappeared. There was either complete disappearance in 24 or 48 hous, or it was still present as a clear cut erithematous papule, smaller than 10 mm in diameter (except for only one case with 10,5 mm). After the disappearing of the injection papule, the inoculated place was without any macroscopic sign (latency period...(AU)^ien.
Descritores:HANSENIASE
ANTIGENO DE MITSUDA/ef adv
ANTIGENO DE MITSUDA/anal
ANTIGENO DE MITSUDA/metab
Meio Eletrônico:http://hansen.bvs.ilsl.br/textoc/revistas/1947/PDF/v15n3/v15n3a04.pdf - pt.
Localização:BR191.1


  2 / 47 HANSEN  
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Texto Completo-pt
Id:25972
Autor:Beiguelman, Bernardo; Quagliato, Reynaldo.
Título:Sôbre a reação de Mitsuda.
Fonte:Rev. bras. Leprol;32(1/4):39-46, jan.-dez. 1964. ^btab, ^bgraf.
Resumo:O problema da correlação entre as respostas macroscópicas e histológicas à inoculação de lepromina é discutido no presente trabalho, chegando-se à conclusão de que os resultados obtidos através do estudo de amostras de doentes de lepra não podem ser aplicados a populações sadias. Chama-se a atenção para o fato de que ainda não foi demonstrado terem agentes sensibilizantes, tais como o BCG ou as inoculações repetidas de lepromina, a capacidade de transformar indiv¡duos histológicamente Mitsuda negativos em Mitsuda positivos. Também não parece provado que as reações positivas ao teste leprom¡nico possam ocorrer na ausência de hipersensibilização por M. tuberculosis e/ou M. leprae, ou outro agente semelhante. A suposição de que as LR +++ observadas em indiv¡duos sadios devam corresponder invariávelmente a reações histológicamente positivas pode causar tendenciosidades. (AU)^ipt.
Descritores:Antígeno de Mitsuda/ef adv
Antígeno de Mitsuda/bios
Antígeno de Mitsuda/farmacol
Antígeno de Mitsuda/fisiol
Antígeno de Mitsuda/tox
Hanseníase/imunol
Hanseníase/fisiopatol
Limites:Humanos
Masculino
Feminino
Recém-Nascido
Lactente
Pré-Escolar
Criança
Meio Eletrônico:http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1964/PDF/v32n1-4/v32n1-4a05.pdf - pt.
Localização:BR191.1


  3 / 47 HANSEN  
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Texto Completo-pt
Id:25926
Autor:Souza Campos, N; Leser, W; Bechelli, L. M; Quagliatio, R; Rotberg, A.
Título:Viragem da lepromino-reação em função de diferentes estímulos. Influência da idade, nessa viragem, no grupo etário de 6 a 43 meses.
Fonte:Rev. bras. Leprol;30(1/2):3-20, jan.-jun. 1962. ^btab.
Resumo:112 crianças, 56 de cada sexo, com idades variando de 6 a 34 meses, tuberculino-negativas, foram alotadas em quatro grupos experimentais, a saber: Grupo A - recebeu uma dose de BCG por via intradérmica; Grupo B - recebeu três inoculações do ant¡geno de Mitsuda com intervalos de 1 mês; Grupo C - recebeu três doses de BCG por via oral, com intervalo de 1 semana; Grupo D - testemunha. O alotamento foi feito sorteando-se pelos quatro grupos as 4 crianças mais velhas de cada sexo, em seguida as 4 mais velhas das restantes e assim por diante. Um mês após a última inoculação do ant¡geno de Mitsuda, foi feita a reação de Mitsuda em tôdas as crianças, sendo os resultados lidos por três leprólogos experimentados, idependentemente, e sem conhecimento do grupo experimental a que pertencia cada criança. Tôda a análise estat¡stica foi feita por métodos não paramétricos. Seus resultados mostraram, desde logo, que não pode ser aceita, ao n¡vel de 5% pré-fixado, a hipótese de igualdade de intensidade da reação nos quatro grupos. Verificando-se que pode ser aceita a hipótese de igualdade, quanto á intensidade da reação, entre os sexos, e considerando que, do ponto de vista prático, interessa primordialmente a distinção entre reações expressas por ++ ou +++, de um lado, e...(AU)^ipt.
Descritores:Hanseníase/ind quim
Hanseníase/quimioter
Hanseníase/imunol
Hanseníase/fisiopatol
Antígeno de Mitsuda/ef adv
Antígeno de Mitsuda/anal
Antígeno de Mitsuda/imunol
Mycobacterium bovis/ef drogas
Mycobacterium bovis/imunol
Mycobacterium bovis/fisiol
Limites:Humanos
Masculino
Feminino
Pré-Escolar
Criança
Adolescente
Adulto
Meia-Idade
Idoso
Meio Eletrônico:http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1962/PDF/v30n1-2/v30n1-2a01.pdf - pt.
Localização:BR191.1


  4 / 47 HANSEN  
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Id:22116
Autor:Basombrío, G; Gatti, J. C; Cardama, J. E; Colombo, C. V; Wilkinson, F. F.
Título:Reaction to lepromin in healthy and affected skin.
Fonte:Int. J. Lepr;19(2):161-164, Apr.-Jun. 1951. tab.
Resumo:La prueba de la lepromina se a´plicó a 65 pacientes leprosos en dos áreas cutáneas simultaneamente,un área de apariencia normal, otra con lesión evidente. El 71 por ciento de los pacientes reaccionaron de igual manera en ambas areas, ya positivos, ya negativos. En el grupo del tipo tuberculoide, donde hubo diferencias enh la reacción, ésta fué más frecuentemente de mayor intensidad en la piel afectada que en la piel normal. En el grupo del tipo lepromatosos, el efecto fué todo lo contrario: las reacciones más fuertes fueron más frecuentes en la piel du aquariencia normal que en la piel con lesiones. En un pequeño grupo de clasificación indeterminada na hubo tales diferencias en las reacciones cutáneas a la lepromina. (AU).
Descritores:HANSENIASE
ANTIGENO DE MITSUDA/ef adv
ANTIGENO DE MITSUDA/clas
Meio Eletrônico: - .
Localização:BR191.1


  5 / 47 HANSEN  
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Id:21916
Autor:Leiker, D. L.
Título:Studies on the lepromin test. IV. Influence of leprosy on the reactions to lepromin tuberculin, and the "875 bacillus" suspension.
Fonte:Int. J. Lepr;29(4):496-501, Oct.-Dec. 1961. tab.
Resumo:Not all lepromatous patients are completely anergic to lepromin, as a weak response has been seen in many such cases. A correlation between clinical symptoms and the size of the lepromin reaction was found when different groups of these patients were compared. The selection of these groups was based mainly upon the definition of the margin of the lesions, the degree of infiltration, and the degree of symetry of distribution. Some histologic differences between the groups are also described. It is concluded that phagocytosis of the bacilli is the expression of a very weak resistance to M. leprae. Only cases of the pure diffuse variety of lepromatous leprosy are completely anergic to lepromin. When lepromin is injected in an infiltrated skin, no reaction can be expected because the skin has already reacted to the greater number of living bacilli already present. After treatment, when the bacilli have disappeared, a nondiffuse patient may show a weak response to lepromin. Then the conversion of the reaction is not a real one. It was found that the...(AU).
Descritores:HANSENIASE
HANSENIASE/diag
ANTIGENO DE MITSUDA/ef adv
Meio Eletrônico: - .
Localização:BR191.1


  6 / 47 HANSEN  
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Id:21915
Autor:Leiker, D. L.
Título:Studies on the lepromin test. III. Influence of tuberculosis contact and other factors on the size of the lepromin reaction.
Fonte:Int. J. Lepr;29(4):488-495, Oct.-Dec. 1961. tab, graf.
Resumo:In performing the tuberculin test, especially in countries with a high prevalence of nonspecific tuberculin reactions, several technical factors are of great importance with respect to accuracy of the results. In every country or area the border between specific and nonspecific reactions must be defined before drawing conclusions about the relation between tuberculin and lepromin reactions. If this is done properly it is evident that the effect of infection with M. tuberculosis on the size of the lepromin reactions is important. It is not permitted to draw conclusions about resistance to leprosy from a negative lepromin reaction, when the tuberculin reaction is not known. The size of the lepromin reaction is limited by young age. Besides M. leprae and M. tuberculosis, other acid-fast bacilli have an influence on the size of the lepromin reaction, but the influence is slower and weaker. The hypothesis of Rotberg that an endogenous factor ("N factor") is necessary to enable an individual to develop resistance to M. leprae would explain much about the epidemiology of leprosy, if this factor is a quantitative and hereditary one. In addition to this factor one has to assume one or more local tissue factor to explain such clinical findings as the "immune area" (Wade). Theoretically it is improbable that tuberculosis contact or BCG vaccination has any effect on the N factor. In practice, however, evidence was found that previous tuberculosis cntact gives some protection against leprosy in part of the population, probably only in those people who possess the endogenous factor which enables them to develop some degree of immunity. (AU).
Descritores:HANSENIASE
HANSENIASE/diag
ANTIGENO DE MITSUDA/ef adv
Meio Eletrônico: - .
Localização:BR191.1


  7 / 47 HANSEN  
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Id:21865
Autor:Brown, J. A Kinnear; Short, G. Murray; Blenska, W; Kooij, R.
Título:"Lepromin" reactions with normal - tissue preparations. (Correspondence).
Fonte:Int. J. Lepr;25(3):271-275, July-Sept. 1957. .
Descritores:HANSENIASE
HANSENIASE/clas
ANTIGENO DE MITSUDA/ef adv
Meio Eletrônico: - .
Localização:BR191.1


  8 / 47 HANSEN  
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Id:21824
Autor:Wade, H. W.
Título:Agammaglobulinemia and the lepromin reaction? (Editorials).
Fonte:Int. J. Lepr;25(4):395-398, Oct.-Dec. 1957. .
Descritores:HANSENIASE
ANTIGENO DE MITSUDA/ef adv
Meio Eletrônico: - .
Localização:BR191.1


  9 / 47 HANSEN  
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Id:21723
Autor:Guinto, Ricardo S; Mabalay, Mario C.
Título:The lepromin reaction in tuberculoid reaction cases. (Correspondence).
Fonte:Int. J. Lepr;26(2):157-159, Apr.Jun. 1958. tab.
Descritores:HANSENIASE TUBERCULOIDE/diag
HANSENIASE
ANTIGENO DE MITSUDA/ef adv
Meio Eletrônico: - .
Localização:BR191.1


  10 / 47 HANSEN  
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Id:21722
Autor:Fernandez, J. M. M.
Título:The tuberculosis factor in reactivity to lepromin. (Correspondence).
Fonte:Int. J. Lepr;26(2):155-157, Apr.Jun. 1958. tab.
Descritores:HANSENIASE
ANTIGENO DE MITSUDA/ef adv
ANTIGENO DE MITSUDA/clas
Meio Eletrônico: - .
Localização:BR191.1


  11 / 47 HANSEN  
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Id:21712
Autor:Yamamoto, Y; Nishiura, M; Harada, N; Imaeda, T.
Título:Electron microscopy of Mycobacterium leprae murium in ultra-thin sections of murine leprosy lesions.
Fonte:Int. J. Lepr;26(2):111-114, Apr.Jun. 1958. ilus.
Resumo:1- Lepromas of murine leprosy were studied in ultra-thin sections with the electron microscope. 2- The cell wall, cytoplasm and nuclear elements of M. leprae murium are described. 3- Around each bacillus there is a distinct electron-transparent zone which distinguishes them from other cytoplasmic components of the leproma cells. 4- Foamy structures as are seen in human lepra cells were not observed. (AU).
Descritores:HANSENIASE
MYCOBACTERIUM LEPRAEMURIUM/clas
ANTIGENO DE MITSUDA/ef adv
ANTIGENO DE MITSUDA/clas
Meio Eletrônico: - .
Localização:BR191.1


  12 / 47 HANSEN  
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Id:21711
Autor:Trappmann, R.
Título:A study of the lepromin and tuberculin reactions. The correlation between the two reactions and the influence of BCG vaccination on nonreactors in healthy leprosy contact children in Djakarta.
Fonte:Int. J. Lepr;26(2):102-110, Apr.Jun. 1958. tab.
Resumo:1- Lepromin and tuberculin tests have been made on 901 healthy leprosy-contact children between the ages of 1 and 15 years. They showed in total a much lower Mantoux than Mitsuda rate, 30 vs 61 per cent. With growing age the number of reactors to both tests increased markedly, but in the third age group (11-15 years) the number of tuberculin reactors increased much more markedly than that of the Mitsuda reactors. This finding is attributed to the fact that the younger children had had almost exclusively contact with their leprous environment, whereas the older children had wider contact with the normal population in schools and playgrounds, where they had greater chances of meeting tuberculosis infection. 2- In the correlation between the tuberculin and lepromin reactions, there was agreement between the two reactions (simultaneouly positive or negative) of 59 per cent. The positive association was 25 per cent. Among the nonagreeing reactions the tuberculin-negative, Mitsuda-positive group was the largest, about 36 per cent. Assuming that the tuberculin positivity was induced by previous contact with leprosy, there was found a positive association of the two tests in 41 per cent (in 25, 47 and 52 per cent in the respective age groups), and a positive tuberculin reaction associated with lepromin negativity in 14 per cent (6, 15 and 72 per cent respectively). These figures show little evidence of tuberculin positivity having been induced by contact with the Hansen bacillusAssuming induction of MItsuda positivity by previous contact with tuberculosis, there was found a positive association of the two reactions in 83 per cent (40, 58 and 90 per cent in the respective age groups). A certain degree of influence on the MItsuda reaction by tuberculosis cannot be denied, since of 277 tuberculin reactors 83 per cent are also lepromin positive. At the same time, however, it was found that positive Mitsuda reactions occurred in 52 per cent independently of the tuberculin reaction, probably through contact with leprosy itself...(AU).
Descritores:HANSENIASE
HANSENIASE/clas
HANSENIASE/diag
ANTIGENO DE MITSUDA
ANTIGENO DE MITSUDA/ef adv
Meio Eletrônico: - .
Localização:BR191.1


  13 / 47 HANSEN  
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Id:21693
Autor:Kitano, Hiroichi; Inoué, Takeo.
Título:The Mitsuda reaction by vaccines treated with the ultra-supersonic wave.
Fonte:Int. J. Lepr;9(1):29-38, Jan.-Mar. 1941. ilus, tab.
Resumo:The purpose of the work here reported was to determine whether or not the Mitsuda reaction can be produced by leproma emulsions in which the bacillary elements have been destroyed, at least to the point of loss of acid-fastness, by application of ultra-supersonic waves. Vaccines so prepared, it has been found, retain antigenic capacity, though it is much weakened. They are similar to the standard Mitsuda antigen in that they fail to cause positive reactions in lepromatous cases, while neural-type cases and healthy persons react positively. The quality of the U-vaccine is not affected by heating. In view of the fact that all of the components of the bacilli remain in the U-vaccine, the weakening of the reaction indicates that it depends upon the presence of the formed leprosy bacilli themselves. This is further indicated by the fact that a filtrate of the U-vaccine is incapable of producing positive reactions, though it must contain all of the soluble bacterial substances. On the other hand, it is also a fact that the small numbers of bacilli present in the U-vaccine can, in some healthy persons and maculo-neural cases, cause reactions approximately as strong as those induced by the Mitsuda antigen itself. The fact that few bacilli can cause strong reactions has already been proved with diluted Mitsuda vaccine in cases of "akuter Schub". The same results have been obtained with the U-vaccine containing small numbers of bacilli that are losing their acid-fastness. Why can the U-vaccine cause the Mitsuda reaction, despite the fact that it may contain nothing which can be stained by methylene blue or by the Ziehl-Neelsen method? It is a fact that this preparation is turbid, though of course much less so than the original Mitsuda vaccine. Yhis turbidity is due to a mass of fine bacillary particles that are not acid-fast. These particles still retain the capability of causing the Mitsuda reaction, though of much weakened grade. This agrees with Hayashi's findings with leprosy bacilli treated with hydrochloric acid. The fact that, contrary to our expectations, the filtrate of this vaccine does not cause the same reaction as the unfiltered substance is further evidence of the essential nature of the Mitsuda reaction. Comparing this filtrate and one of the Mitsuda vaccine, the former, in the first several days, caused stronger reactions than the latter in healthy and neural persons,...(AU).
Descritores:ANTIGENO DE MITSUDA/ef adv
ANTIGENO DE MITSUDA/anal
ANTIGENO DE MITSUDA/isol
Limites:HUMANO
Localização:BR191.1


  14 / 47 HANSEN  
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Id:21671
Autor:Sato, Saburo; Fukuda, MInoru.
Título:Marked increase in Mitsuda positivity in lepromatous cases with reference to clinical features.
Fonte:Int. J. Lepr;26(3):205-218, July-Sept. 1958. tab.
Resumo:1- The nominally high positive rates of the Mitsuda reaction in acses of lepromatous leprosy, 80 per cent and more, were observed in two surveys, made in 1954 and 1957. Clinical analyses have been made of 840 out of some 1,400 cases surveyed in 1954, and of 177 cases that were examined on both occasions. 2- The main cause of the phenomenon is believed to be marked enhancement of the power of resistance against the leprosy infection resulting from modern chemotherapy. 3- It has now become difficult to apply the Mitsuda reaction in the classification of leprosy, so long as either the Madrid or the WHO criterion of positivity is employed. In view of the findings reported, it is proposed that over 7 mm. be made the limit for positive readings. 4 The position of the Mitsuda test in the study of leprosy may be said to be ever more important, because the reaction expresses the state of resistance of the organism against the infection under existing conditions. (AU).
Descritores:HANSENIASE VIRCHOWIANA/clas
HANSENIASE VIRCHOWIANA/diag
HANSENIASE
ANTIGENO DE MITSUDA/ef adv
Meio Eletrônico: - .
Localização:BR191.1


  15 / 47 HANSEN  
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Id:21665
Autor:Fernandez, J. M. M; Yanagisawa, K; Aleixo, J; Bechelli, L. M; Kuper, S. W. A; Leite, A. Salazar; Wade, H. W.
Título:Immunology: the lepromin reaction.
Fonte:Int. J. Lepr;26(4):385-389, Oct.-Dec. 1958. .
Conferência:Apresentado em: International Congress of Leprology, 7 - Tokyo, Japan, s.l, November 12-19, 1958.
Descritores:HANSENIASE
ANTIGENO DE MITSUDA
ANTIGENO DE MITSUDA/ef adv
ANTIGENO DE MITSUDA/clas
Meio Eletrônico: - .
Localização:BR191.1


  16 / 47 HANSEN  
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Id:21657
Autor:Guinto, R. S; Wade, H. W.
Título:Results of tests with serial dilutions of lepromin in separate groups of normal young children with a comparison of two lepromins and the Dharmendra antigen.
Fonte:Int. J. Lepr;26(4):328-345, Oct.-Dec. 1958. tab, graf.
Resumo:To ascertain whether or not high dilutions of lepromin would be practical for the field testing of normal populations, two series of tests were made with healthy schoolchildren aged 6-9 years. The first series comprised five groups averaging 116 children each, all of Opon poblacion (town), the second one five groups averaging 92 each, all of outlying barrios (rural villages). None had been lepromin tested before or BCG vaccinated, and none was given more than one injection of lepromin. In the first series two lepromins made by different methods (M, by Mabalay, and W, By Wade) were compared with each other and with the Dharmendra antigen, and two dilutions (1/10 and 1/20) of the stock W lepromin were also used. The tests in the second series were with five concentrations of the W lepromin: 1/1 (i.e., undiluted), 1/10, 1/20, 1/40 and 1/80. With respect to the late reaction, the two lepromins in Series 1 gave the same results, 75 per cent positives. The M stock, however, elicited fewer early reactions than the W stock, suggesting that boiling may be less effective than autoclaving in freeing the soluble antigenic elements involved in that reaction. In series 2 the full-dose W lepromin gave rise to more positive reactions of both kinds than it had in Series 1, and the dilutions gave increasingly large differences with respect to the late reaction. The Dharmendra antigen proved ineffective in eliciting either type of response in these very young and immature subjects, this result with the late reaction probably due to the extraction of the lipids during manufacture....(AU).
Descritores:HANSENIASE/clas
HANSENIASE/diag
ANTIGENO DE MITSUDA/admin
ANTIGENO DE MITSUDA/ef adv
Limites:ESTUDO COMPARATIVO
CRIANÇA
Meio Eletrônico: - .
Localização:BR191.1


  17 / 47 HANSEN  
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Id:21624
Autor:Doull, James A; Guinto, Ricardo S; Mabalay, Mario C.
Título:The origin of natural reactivity to lepromin. The association between the Mitsuda reaction and reactions to graded doses of tuberculin.
Fonte:Int. J. Lepr;27(1):31-42, Jan.-Marc. 1959. tab.
Resumo:This study deals with lepromin reactivity of the Mitsuda type, observed in apparently healthy children on MActan Island, Cebu, Philippines. The principal theories which have been offered to explain this type of reactivity are prior infection with M. leprae, with M. tuberculosis, or with some other species of mycobacteria. It is improbable that the majority of these children, and especially those under three years of age, could have been exposed to leprosy. Although there is a positive correlation between reactivity to tuberculin and that to lepromin, the excess of lepromin reactors among tuberculin positives over the number e´xpected if there were no association comprises a very small fraction of the total number reacting to lepromin. This is true both for small doses of tuberculin, reaction to which is regarded as specific for infection with M. tuberculosis, and for larger doses which may indicate prior infection with other species of Mycobacterium. This suggests that lepromin reactivity among these children is caused in most instances by some factor other than infection with M. tuberculosis or any related species. The theory that the test dose of lepromin is the responsible sensitizing factor is not in itself adequate as far as can be judget from the effect of a second lepromin test in a controlled study...(AU).
Descritores:HANSENIASE
HANSENIASE/diag
ANTIGENO DE MITSUDA/ef adv
Meio Eletrônico: - .
Localização:BR191.1


  18 / 47 HANSEN  
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Id:21561
Autor:Lara, C. B.
Título:Mitsuda's skin reaction (lepromin test) in children of leprous parents. II. Observations on newly-born to eighteen-month-old children.
Fonte:Int. J. Lepr;8(1):15-28, Jan.-Mar. 1940. tab.
Resumo:One hundred and ten unisolated nonleprous children of leprous parents, ranging in age from newly-born to eighteen months, all closely observed since birth, were given the lepromin test repeatedly at intervals of four months, with special attention to the appearance of early, recognizable lesions of leprosy, and the results of the tests were analyzed and correlated with the clinical observations. Sex was found to have on the lepromin reaction. The frequency of positive reactions was in direct relation to the age, a small but not negligible proportion of undoubtedly positive reactions accurring, in the first test, among the children less than one year old. In the retests there was a further progressive increase in the proportion of positive reactors which could not wholly be attributed to further ageing, but was probably in part the effect of retesting. Thus a majority of the children who were still less than one year old gave definitely positive reactions in the second or third test. Retesting of strongly positive reactors with a markedly reduced dose of lepromin more frequently resulted in a distinctly diminished reaction in the absence of manifest leprosy than when lesions were already in evidence. The appearance or existence of early leprotic lesions in the children was associated with an apparently undiminished, and possibly even greater tendency to react positively to the test. Both the duration and the constancy of exposure to leprous environment seemed also to bear a direct relation to the proportion of positive reactions.Intercurrent disease not of a serious nature showed no depressing influence on the reaction. (AU).
Descritores:HANSENIASE
ANTIGENO DE MITSUDA/admin
ANTIGENO DE MITSUDA/ef adv
ANTIGENO DE MITSUDA/imunol
Limites:HUMANO
Localização:BR191.1


  19 / 47 HANSEN  
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Id:21421
Autor:Lima, Lauro de Souza; Fernandez, J. M. M; Schujman, Salomon; Basombrio, Guillermo.
Título:The lepromin reaction in tuberculoid reaction cases. (Correspondence).
Fonte:Int. J. Lepr;24(1):86-87, Jan.-Mar. 1956. .
Descritores:HANSENIASE TUBERCULOIDE/compl
HANSENIASE TUBERCULOIDE/diag
HANSENIASE
ANTIGENO DE MITSUDA/ef adv
Meio Eletrônico: - .
Localização:BR191.1


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Id:21255
Autor:Fernandez, Jose M. M.
Título:Question of optimal site for the lepromin test. (Correspondence).
Fonte:Int. J. Lepr;25(1):58-58, Jan.-Mar. 1957. .
Descritores:HANSENIASE
HANSENIASE/clas
HANSENIASE/diag
ANTIGENO DE MITSUDA/ef adv
ANTIGENO DE MITSUDA/clas
Localização:BR191.1



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